The dysregulation of the serotonergic system has long been recognized as an important factor underlying the pathophysiology of\r\nPTSD. To date, SSRIs have already been established as the firstline pharmacotherapeutic agents for treating acute and chronic PTSD.\r\nHowever, SSRIs largely have several disadvantages which limit their utility. Our previous study has also shown that administration\r\nof the total flavonoids, isolated from the extract of Xiaobuxin-Tang (XBXT, mild mind-easing decoction), comprising four Chinese\r\nmedicines including Haematitum, Flos Inulae, Folium Phyllostachydis Henonis, and Semen Sojae Preparatum, exerted significant\r\nantidepressant-like effect in chronically mildly stressed rats, possibly mediated by serotonergic activation. Since the central\r\nserotonergic dysfunction is an important and well-known cause mediating the pathophysiology of trauma-related symptoms in\r\nPTSD, it is reasonable to predict that flavonoids may exert therapeutic effects on PTSD in animal models. Therefore, the present\r\nstudy aims to examine the effect of flavonoids in alleviating the enhanced anxiety and fear response induced in two PTSD animal\r\nmodels. Ser, an SSRI, was administered as a positive control. Furthermore, the changes of brain monoaminergic neurotransmitters\r\nafter chronic flavonoids administration have also been assessed in SPS-treated rats.
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